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Most types of magic mushrooms are of the genera that contain psilocybin and psilocin. These mushrooms are not toxic and will not cause liver damage. However there are other similar mushrooms that will cause liver damage if eaten. They contain toxins called amatoxins. The specific mushrooms which contain these amatoxins are mostly from the genera Amanita, Galerina, Lepiota, and Conocybe. Amatoxin poisoning is responsible for most mushroom poisoning fatalities. Death is usually in 7 to 10 days due to liver failure.

The legal availability of Psilocybe mycelium varies by country and state. Most of the other supplies needed for mushroom cultivation are easily obtained. It is not difficult to cultivate a Psilocybe mushroom especially Psilocybe cubensis which is why many mushroom enthusiasts attempt to cultivate their own batches.