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A typical dose of the species Psilocybe cubensis is approximately 1 to 2 grams, corresponding with 10 to 25 milligrams psilocybin and psilocin. A huge dose for one person ranges from 2 ½ to 5 grams dried material or 25 to 50 milligrams of psilocybin and psilocin.

Psilocybe mushrooms have been the subject of several studies that documented its potential positive benefits, as well as cleared up any questions about the fact that magic mushrooms are not addictive. Due to these reasons, the Schedule I drug classification has come under fire in some sectors.