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Instead of the compounds psilocybin and psilocin that characterize the magic mushrooms of the Psilocybe and Panaeolus types, Amanita muscaria and Amanita pantherina both contain ibotenic acid and muscimol, two other psychoactive substances.

A total absence of any type of hallucinogenic effect is possible, even when taking magic mushrooms in large doses. This depends on the species and to a much lesser degree the variety of the particular magic mushrooms, substrate they grew from, the conditions of growth and the general quality of the harvested batch.