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Amanita muscaria, commonly known as the fly agaric or fly Amanita, is a poisonous and psychoactive basidiomycete fungus, one of many in the genus Amanita. Native throughout the temperate and boreal regions of the Northern Hemisphere, Amanita muscaria has been unintentionally conveyed to many countries in the Southern Hemisphere, generally as a symbiont with pine plantations, and is now a true cosmopolitan species. It associates with various deciduous and coniferous trees. The quintessential toadstool, it is a large imposing white-gilled, white-spotted, usually deep red mushroom, one of the most recognizable and widely encountered in popular culture. Though generally considered poisonous, Amanita muscaria is otherwise famed for its hallucinogenic properties with its main psychoactive constituent being the compound muscimol. The mushroom has had a religious significance in Siberian culture and possibly also in ancient Indian and Scandinavian cultures.

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During the 16th century, the Xochipilli figure was carved. The Aztec statue depicts Xochipilli, the Prince of Flowers decorated with six psychoactive plants: mushrooms, tobacco, morning glory, sinicuichi, cacahuaxochitl, and one unidentified plant. The mushroom represented on the statue has since been identified as the magic mushroom species Psilocybe aztecorum, which is known to be only from the region around the volcano Popocatepetl where the statue was found later on.