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Amanita muscaria, commonly known as the fly agaric or fly Amanita, is a poisonous and psychoactive basidiomycete fungus, one of many in the genus Amanita. Native throughout the temperate and boreal regions of the Northern Hemisphere, Amanita muscaria has been unintentionally conveyed to many countries in the Southern Hemisphere, generally as a symbiont with pine plantations, and is now a true cosmopolitan species. It associates with various deciduous and coniferous trees. The quintessential toadstool, it is a large imposing white-gilled, white-spotted, usually deep red mushroom, one of the most recognizable and widely encountered in popular culture. Though generally considered poisonous, Amanita muscaria is otherwise famed for its hallucinogenic properties with its main psychoactive constituent being the compound muscimol. The mushroom has had a religious significance in Siberian culture and possibly also in ancient Indian and Scandinavian cultures.

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Psilocybin and psilocin are listed as Schedule I drugs under the United Nations 1971 Convention on Psychotropic Substances. Thus, the ownership and subsequent personal dealings with Psilocybe mushrooms is therefore prohibited by extension.

The magic mushroom Psilocybe zapotecorum can be found throughout much of the subtropical regions of Mexico, Central America, and South America.